Throughout our bodies, exists the endo-cannabinoid system (ECS).
An abundance of Cannabinoid Receptors which exist solely for the purpose of absorbing molecules from the cannabis plant. A highway of receptors known as CB1 and CB2 which anecdotal evidence suggests can affect everything from depression to sleep – to a therapeutic level anyway the legal and geopolitical contradictions on this are a phenomenal . Another topic for another day! But what do these receptors do? What purpose do they serve?
Discovered respectively in 1990 and 1993, these Cannabinoid Receptors are involved in a variety of physiological processes including appetite, pain sensation and memory. That said, recent explorations have revealed that stimulating these receptors can give benefit to the body in so many more ways. They even mediate the psychoactive effects of cannabinoids like THC.
CB1 Cannabinoid Receptors are predominantly found in the brain and head region in abundance, although are found throughout the body with lesser populations. It would seem that these receptors have affect on everything metabolic. they are also in the lungs, vascular system, Muscles, Gastrointestinal tract, reproductive organs , immune system, bone marrow, liver and pancreas.
CB2 receptors are found in the spleen, immune system, liver, bone marrow, pancreas but most famously the skin – hence the ever growing success of our cooling gel, muscle balm and sensitive salves.
There is no doubt that the discovery of these receptors caused waves of excitement within the cann-communities. But there’s more! In 1999 another receptor fitting the “G” protein (GPR55) was discovered in the hippocampus region of the brain as well as the cerebellum. It has more recently been found in areas like the gastrointestinal tract, spleen and adrenal glands. Its safe to say this one is worth getting excited about too, because the GPR55 or CB3 receptor has been found in cancer cells as well as in some of the most vital parts of the body and even in areas of trauma – leading to speculation by various scholarships that CB3 could be the next big game changer for the cannabinoid industry- To be clear that’s all at a theoretical stage and there has been little or no published citations on the matter.
Find out more about the CB3 Receptors at: